Therapeutic Category
Anti-infective
PRUXONE
Injectable ceftriaxone and ceftriaxone-sulbactam presentations for anti-infective treatment needs.
Anti-infective Brand
PRUXONE
PRUXONE is an injectable anti-infective range based on ceftriaxone, including monotherapy strengths and a ceftriaxone-sulbactam combination presentation.
Presentations
Ceftriaxone and Ceftriaxone/Sulbactam injections
Administration
I.M. and I.V. use
Strengths
500 mg to 2000 mg and 1.5 gm combo
Packshot not available
Brand Name
PRUXONE
Product Name
PRUXONE 2000
Generic Name
Combipack of Ceftriaxone for Injection 2000 mg and Sterilised Water for Injections
Dosage Form
Dry injection
Pack Size
1 vial
PRUXONE 2000
Combipack of Ceftriaxone for Injection 2000 mg and Sterilised Water for Injections
Therapeutic Indication
Ceftriaxone injection presentation within the PRUXONE anti-infective range.
Dosage and Method of Administration
Use exactly as directed by a physician or institutional protocol.
Mode of Administration
I.M./I.V. use.
Packshot not available
Brand Name
PRUXONE
Product Name
PRUXONE 500
Generic Name
Combipack of Ceftriaxone for Injection 500 mg and Sterilised Water for Injections
Dosage Form
Dry injection
Pack Size
1 vial
PRUXONE 500
Combipack of Ceftriaxone for Injection 500 mg and Sterilised Water for Injections
Therapeutic Indication
Ceftriaxone injection presentation within the PRUXONE anti-infective range.
Dosage and Method of Administration
Use exactly as directed by a physician or institutional protocol.
Mode of Administration
I.M./I.V. use.
Brand Name
PRUXONE
Product Name
PRUXONE 1000
Generic Name
Combipack of Ceftriaxone for Injection 1000 mg and Sterilised Water for Injections
Dosage Form
Dry injection (IV use)
Pack Size
1 vial
PRUXONE 1000
Combipack of Ceftriaxone for Injection 1000 mg and Sterilised Water for Injections
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Therapeutic Indication
PRUXONE 1000 is a broad-spectrum bactericidal cephalosporin antibiotic indicated for the treatment of bacterial meningitis, community-acquired pneumonia, hospital-acquired pneumonia, intra-abdominal infections, acute otitis media, complicated urinary tract infections including pyelonephritis, infections of bones and joints, complicated skin and soft tissue infections, gonorrhoea, syphilis, and bacterial endocarditis in adults and children including term neonates from birth.
Dosage and Method of Administration
The dose depends on the severity, susceptibility, site and type of infection, and on the age and hepato-renal function of the patient.
Recommended dosing should follow the approved tables and product information for the specific indication.
In particularly severe cases, doses at the higher end of the recommended range should be considered.
Mode of Administration
I.M./I.V. use.
Brand Name
PRUXONE
Product Name
PRUXONE S
Generic Name
Combipack of Ceftriaxone and Sulbactam for Injection 1.5 gm and Sterilised Water for Injections BP
Dosage Form
Dry injection
Pack Size
1 vial
PRUXONE S
Combipack of Ceftriaxone and Sulbactam for Injection 1.5 gm and Sterilised Water for Injections BP
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Therapeutic Indication
Ceftriaxone with sulbactam is indicated for lower respiratory tract infections, acute otitis media, skin and skin structure infections, urinary tract infections, bone and joint infections, intra-abdominal infections, septicaemia, meningitis, and gonorrhoea caused by susceptible organisms.
Dosage and Method of Administration
Adults: the recommended dosage is 1.5 g to 3 g every 6 hours, representing 1 g ceftriaxone plus 0.5 g sulbactam up to 2 g ceftriaxone plus 1 g sulbactam.
The total dose of sulbactam should not exceed 4 g per day.
The usual adult daily ceftriaxone dose is 1 g to 2 g once daily, or in equally divided doses twice daily, depending on infection type and severity. Total daily dose should not exceed 4 g.
Adjust the regimen in patients with marked renal impairment. In patients with creatinine clearance below 15 ml/min, the maximum sulbactam dose should be 500 mg every 12 hours.
Neonates up to 14 days: 20 to 50 mg/kg once daily, not exceeding 50 mg/kg/day.
Infants and children 15 days to 12 years: 20 to 80 mg/kg once daily. Children weighing 50 kg or more should receive the usual adult dose.
Intravenous doses of not less than 50 mg/kg should be infused over at least 30 minutes.
For Streptococcus pyogenes infections, therapy should continue for at least 10 days.
Mode of Administration
I.V./I.M. use.